Jerzy Leszek

Department and Clinic of Psychiatry, Wroclaw Medical University, Wyb. L. Pasteura 10, 50-367, Wrocław, Poland.

2 papers in the library · 12 citations · publishing 2024-2025

Papers

Innovative approaches in the treatment-resistant depression: exploring different therapeutic pathways.

GeroScience March 25, 2025 Anna Łysik, Katarzyna Logoń, Aleksandra Szczygieł et al. 8 citations

Treatment-resistant depression (TRD) affects many people with major depressive disorder, and standard medications often fall short. This review covers recent advances, including non-pharmacological therapies like transcranial magnetic stimulation, deep brain stimulation, electroconvulsive therapy, and vagus nerve stimulation, along with their mechanisms. Novel drugs such as ketamine and esketamine show promise; esketamine has been available in Poland since 2023. Electroconvulsive therapy remains effective, with side effects like temporary memory issues, headache, or cardiovascular changes. Transcranial magnetic stimulation is non-invasive and recommended by psychiatric organizations. Deep brain stimulation is newer and carries surgical risks. Vagus nerve stimulation appears promising as an adjunct, especially at higher doses, with no reported side effects. Personalized approaches are key, and future research should refine techniques, improve safety, and confirm long-term efficacy.

DOI: 10.1007/s11357-025-01615-8 Full text Ketamine Treatment-resistant depression Deep brain stimulation Electroconvulsive therapy +6

The Effectiveness of Mindfulness in the Treatment of Methamphetamine Addiction Symptoms: Does Neuroplasticity Play a Role?

Brain sciences March 27, 2024 James Chmiel, Agnieszka Malinowska, Filip Rybakowski et al. 4 citations

Mindfulness meditation may reduce hunger, risk of relapse, stress, depression, and aggression in people with methamphetamine addiction, and can improve cognitive function, whether used alone or with transcranial direct current stimulation. A review of ten studies using behavioral measures found mindfulness an effective treatment option, potentially by inducing neuroplasticity. No drugs are approved for methamphetamine addiction, and existing treatments have moderate effectiveness, so mindfulness offers a promising avenue. However, the review calls for more high-quality research using neuroimaging and neurophysiological measures to confirm these findings and understand underlying mechanisms.

DOI: 10.3390/brainsci14040320 Full text Addiction Mindfulness Methamphetamine use disorder