Towards an expanded neurocognitive account of ketamine's rapid antidepressant effects.
The international journal of neuropsychopharmacology February 4, 2025 Yingliang Dai, Ben J Harrison, Christopher G Davey et al. 6 citations
Ketamine, a fast-acting antidepressant, works by blocking N-methyl-D-aspartate receptors. While its molecular mechanisms are known, its large-scale neurocognitive effects are less clear. This synthesis links ketamine treatment to changes in brain systems for reward processing, interoception, and self-related cognition. The authors suggest that ketamine's antidepressant effects arise from dynamic, multi-level influences across these functional domains.