Electroencephalography Correlation of Ketamine-induced Clinical Excitatory Movements: A Systematic Review.
The western journal of emergency medicine January 1, 2025 Emine M Tunc, Neil Uspal, Lindsey Morgan et al.
A systematic review of eight studies with 141 subjects found that ketamine administration for procedural sedation frequently triggered electrographic seizures in people with epilepsy, but never in those without. Among 94 subjects with epilepsy, 28% had seizures detectable on EEG after ketamine, compared with 0% of 39 subjects without epilepsy. Clinical excitatory movements were also more common in the epilepsy group (14% vs 5%) and were usually time-linked to the EEG seizures. Children with epilepsy appeared more susceptible than adults. The authors suggest clinicians consider a patient's seizure history when discussing the risks and benefits of ketamine sedation.