Ketamine Treatment for Pediatric Refractory Obsessive: Five Open Label Cases.
Journal of child and adolescent psychopharmacology April 1, 2025 Hannah S Ishimuro, Paula K Yanes-Lukin, Pablo H Goldberg et al. 6 citations
In a small pilot trial, five adolescents with obsessive-compulsive disorder (OCD) who had not responded to first-line treatments received a single intravenous infusion of ketamine. All participants experienced mild dissociative symptoms in the 40 minutes after the infusion, but there were no abnormal vital signs, deaths, or suicidal thoughts during the two-week follow-up. Obsessive-compulsive symptom severity decreased immediately after the infusion but was not sustained over the study period. The average score on the Children's Yale-Brown Obsessive Compulsive Scale fell from 29 before treatment to 26.2 fourteen days later. The results suggest ketamine is well-tolerated in this population and warrants further testing of its efficacy.