Magnesium level and impulsivity during ketamine administration for treatment-resistant mood disorders.
Magnesium research Jakub Słupski, Adam Włodarczyk, Natalia Górska et al.
Impulsive behaviors are common in major depressive disorder and bipolar disorder, raising suicide risk and mood instability. Ketamine, an NMDA receptor antagonist, can produce rapid antidepressant and antisuicidal effects, and magnesium given with low-dose NMDA antagonists reduces anxiety- and depression-like behaviors in animals. This observational study of 49 inpatients with treatment-resistant mood disorders measured impulsivity with the Barratt Impulsiveness Scale (BIS-11) and magnesium levels before and during a four-week course of eight ketamine infusions. Magnesium ion concentration during treatment was not associated with changes in BIS-11 scores. The findings provide no evidence for a relationship between magnesium levels and impulsivity during ketamine therapy.