Repeated administration of a subanesthetic dose of ketamine results in impaired motor and cognitive behavior and differential expression of hippocampal P2X1 and P2X7 receptors in adult mice.
Behavioural brain research March 28, 2025 Teresa Belem Mares-Barbosa, Ares Orlando Cuellar-Santoyo, Victor Manuel Ruiz-Rodríguez et al. 3 citations
Repeated low-dose ketamine given for 14 days impaired nest-building and novel object recognition only in adult mice, not in young mice. In the hippocampus, gene expression of GluN1, P2X4, and P2X7 remained unchanged, while GluA2 and P2X1 increased only in young mice. Protein levels showed opposite patterns: young mice had lower P2X1 and higher P2X7, while adult mice had higher P2X1 and lower P2X7. These results suggest adult mice are more vulnerable to repeated ketamine, and differential P2X1 and P2X7 responses may contribute to behavioral changes.