Inpatient Treatment of Suicidality: A Systematic Review of Clinical Trials.
The Journal of clinical psychiatry January 8, 2025 Ali Abdolizadeh, Brett D M Jones, Maryam Hosseini Kupaei et al. 2 citations
A systematic review of treatments for suicidality among psychiatric inpatients aged 18–65 found that intravenous ketamine produced the most consistent rapid reduction in suicidality among 14 pharmacologic trials. Among 35 nonpharmacologic trials—including chronotherapy, neurostimulation, and psychotherapies—results were mixed, with some interventions showing potential benefit, especially for mood, personality, and trauma-related disorders. Many studies had methodological limitations such as nonrandomized designs and lack of control groups. The review calls for larger, well-designed trials to confirm effectiveness.