Proteomic patterns associated with ketamine response in major depressive disorders.
Cell biology and toxicology January 10, 2025 Nan Zhou, Xiaolei Shi, Runhua Wang et al. 1 citation
Plasma proteomic analysis of 30 major depressive disorder patients before and after two weeks of ketamine treatment identified six proteins pivotal to the drug's antidepressive effect. Immune-response pathways were activated in association with symptom relief. Three pre-treatment proteins strongly predicted which patients would respond to ketamine, offering a potential blood test to personalize treatment.