Ketamine Reduces Avoidance Responses During Re-Exposition to Aversive Stimulus: Comparison Between (S)-Isomer and Racemic Mixture.
Brain sciences December 22, 2024 Clarissa A Moura, Anne N de Sousa-Silva, Ana Lívia Mesquita Soares et al. 1 citation
In stressed mice, neither (R,S)-ketamine nor (S)-ketamine affected the retrieval of avoidance memory, but (S)-ketamine, and to a lesser extent (R,S)-ketamine, reduced avoidance responses during re-exposure to an aversive stimulus. Both forms equally produced antidepressant effects in the tail suspension test. However, only the racemic mixture (R,S)-ketamine induced anxiolytic actions in the open field test. These results suggest that (R,S)-ketamine may be more effective than (S)-ketamine for simultaneously reducing avoidance responses and producing antidepressant and anxiolytic effects in stressed mice.