General Anesthesia Occludes Ketamine's Antidepressant Response in a Rodent Model of Chronic Stress.
Psychedelic medicine (New Rochelle, N.Y.) December 1, 2024 Daniel Markman, Andrzej Z Wasilczuk, Joseph Michael Cichon 2 citations
Ketamine's rapid antidepressant effects in chronically stressed male mice require wakefulness. When the anesthetic isoflurane was coadministered at either sedative or general anesthetic doses, ketamine no longer produced dissociative-like behaviors or distinct neuronal activity patterns in prefrontal cortex pyramidal neurons, and antidepressant-like behavioral responses and the molecular plasticity marker c-Fos failed to appear 24 hours later. These results indicate that suppressing psychedelic-induced experiences by altering consciousness may impair activity-dependent plasticity mechanisms necessary for ketamine's therapeutic actions.