Depression, post-traumatic stress disorder, suicidal ideation and ketamine: a case report.
Journal of medical case reports December 24, 2024 S Asad, K Latifzai, V T Eliopoulos et al. 1 citation
Two patients with chronic, treatment-resistant conditions—a 56-year-old man with PTSD and suicidal ideation and a 52-year-old woman with major depressive disorder—received ketamine infusions (nine over 18 months for the man, five over one month for the woman). Both experienced significant and sustained symptom improvement. Electroencephalogram recordings showed distinct changes in brain activity that persisted for months after treatment, suggesting altered brain function. Ketamine may offer relief for some patients with refractory depression and PTSD, but more research is needed to understand how it works and to refine treatment protocols.