Qi Wang

Department of Anesthesiology, Huashan Hospital, Fudan University, Shanghai 200040, China.

2 papers in the library · 15 citations · publishing 2023-2025

Papers

The mechanism and effectiveness of mindfulness-based intervention for reducing the psychological distress of parents of children with autism spectrum disorder: A protocol of randomized control trial of ecological momentary intervention and assessment.

PloS one January 1, 2023 Qi Wang, Siu-Man Ng, Xiaochen Zhou 9 citations

Parents of children with autism spectrum disorder (ASD) experience stressful daily events and psychological distress. Mindfulness can buffer this distress, but its mechanisms are unclear and standard interventions are not tailored to real-life needs. This proposed randomized controlled trial will test a mindfulness-based intervention delivered via a smartphone app with ecological momentary assessment and intervention. The study will recruit 670 parents, randomly assigning 335 to the intervention group and 335 to a control group receiving standard audio instructions. The primary outcome is psychological distress measured by the depression anxiety stress scale; secondary outcomes include subjective well-being and resilience. The intervention is expected to improve cognitive appraisal of stressful events and reduce distress.

DOI: 10.1371/journal.pone.0291168 Full text

Dissociation-related behaviors in mice emerge from the inhibition of retrosplenial cortex parvalbumin interneurons.

Cell reports January 28, 2025 Yue Hu, Yifan Feng, Huoqing Luo et al. 6 citations

In mice, doses of ketamine that cause dissociation inhibit parvalbumin interneurons (PV-INs) in the retrosplenial cortex (RSC), increasing delta oscillations (1-3 Hz) and delta-gamma phase-amplitude coupling (δ-γ PAC) and producing dissociation-like behaviors. Directly inhibiting these neurons without ketamine also triggers delta oscillations, δ-γ PAC, and some dissociation-like behaviors. Activating RSC PV-INs or knocking down the NMDA receptor subunit NR1 and the HCN1 channel in these neurons reduces ketamine-induced delta oscillations, δ-γ PAC, and certain dissociation-like behaviors. The findings identify NR1 and HCN1 as ketamine targets in PV-INs that may cooperatively affect dissociation, suggesting potential therapeutic targets for dissociative symptoms.

DOI: 10.1016/j.celrep.2024.115086 Full text Ketamine Cp: neuroscience Dissociation Parvalbumin interneurons +6