Comparison of Effects of Propofol Combined with Different Doses of Esketamine for ECT in the Treatment of Depression: A Randomized Controlled Trial Protocol.
Neuropsychiatric disease and treatment January 1, 2024 Xuemeng Chen, Rui Zhou, Lan Lan et al. 4 citations
Electroconvulsive therapy (ECT) is effective for treatment-resistant major depressive disorder. Combining esketamine with propofol anesthesia during ECT may improve outcomes. In a randomized, double-blind trial, 111 patients were assigned to receive propofol alone (1 mg/kg), low-dose esketamine (0.25 mg/kg) with propofol (0.75 mg/kg), or higher-dose esketamine (0.5 mg/kg) with propofol (0.5 mg/kg). Outcomes included depression scales, suicide risk, cognitive function, hospital stay, readmission, and side effects. The results may guide better ECT anesthesia choices.