Preoperative Anxiety's Impact on the Median Effective Dose of Esketamine for Alleviating Propofol Injection Pain in Patients Undergoing Painless abortion: A Randomized, Double-Blind, Controlled Trial.
Drug design, development and therapy January 1, 2024 Yanping Shen, Lijun Yin, Binnan Hu et al. 7 citations
A higher dose of esketamine reduces propofol injection pain, but patients who are anxious before surgery need a larger dose than those who are not. In a trial of 150 women undergoing painless abortion, those with preoperative anxiety (STAI-S score ≥40) required an effective dose for 50% of patients (ED50) of 0.133 mg/kg, compared to 0.114 mg/kg for non-anxious women—a statistically significant difference. No differences in side effects or blood pressure stability were seen between groups. Tailoring esketamine dose to a patient's anxiety level may improve pain management during anesthesia.