NeuroImage
January 17, 2008
Andrew C.N. Chen, Weijia Feng, Huixuan Zhao et al.
261 citations
In 15 right-handed healthy college females, high-density EEG recorded during 3 minutes of eyes-closed and 3 minutes of eyes-open resting states revealed distinct spatial patterns of brain activity across frequency bands. Delta (0.5-3.5 Hz) power increased and expanded over the prefrontal area from eyes-closed to eyes-open. Theta (4-7 Hz) power decreased and shifted forward over the fronto-central area. Alpha-1 (7.5-9.5 Hz), alpha-2 (10-12 Hz), and beta-1 (13-23 Hz) powers all decreased over posterior areas. High-frequency beta-2 and gamma bands showed no change. Delta and theta powers showed strong correlation between the two states. Large individual variability in alpha power was observed, especially during eyes-closed. The findings characterize a baseline electrophysiological default mode network for resting brain activity.
Progress in neuro-psychopharmacology & biological psychiatry
January 10, 2025
Peipei Wang, Junmei Hu, Congliang Chen et al.
2 citations
Ketamine, a psychoactive substance strictly regulated by international drug conventions, is classified as a new type drug due to its excitatory, hallucinogenic, or inhibitory effects. The immune regulatory mechanism is the most prominent among several theories explaining ketamine-induced psychiatric symptoms. Recent research highlights the interaction between the immune system and nervous system in neuropsychiatric disorders, with peripheral lymphocyte infiltration into the central nervous system as an early hallmark. This article provides a comprehensive overview of pathophysiological processes in psychiatric disorders, including those from ketamine, covering nerve damage, central immune alterations, and peripheral immune regulation. It emphasizes the crosstalk between peripheral and central immune systems in the onset and progression of psychiatric diseases, offering fresh perspectives on mechanisms, diagnosis, and therapeutic strategies for drug abuse-related mental disorders.
Journal of psychiatry & neuroscience : JPN
January 1, 2024
Peipei Wang, Linzhi Jiang, Junmei Hu et al.
1 citation
In a mouse model of schizophrenia induced by ketamine, the number of peripheral CD3+ T cells increased. Analysis of metabolites in these immune cells and in plasma showed that amino acid metabolism was substantially altered, with elevated levels of glycine, alanine, asparagine, and aspartic acid. The precise amino acid metabolism pathway driving the schizophrenia-like phenotype has not yet been identified. The findings suggest that the metabolic profile of peripheral immune cells could provide biomarkers for diagnosing and treating psychiatric diseases.