Department of Anesthesiology, Central Hospital of Dalian University of Technology, No. 826 Southwest Road, Shahekou District, Dalian, Liaoning Province, China.
2 papers in the library · 31 citations · publishing 2021-2024
Ketamine acts as a rapid and long-lasting antidepressant, but its molecular mechanisms are unclear. In mice subjected to chronic social stress, microRNA miR-98-5p was downregulated in the prefrontal cortex and hippocampus. Overexpressing miR-98-5p with an agonist alleviated depression-like behaviors. Ketamine administration upregulated miR-98-5p, and inhibiting it with an antagonist blocked ketamine's antidepressant effect. This suggests a novel molecular mechanism for ketamine's action and that targeting miR-98-5p could be beneficial for depression treatment.
A bibliometric analysis of 710 publications from 2004 to October 2023 reveals growing research interest in psychedelics as treatments for depression. The analysis maps annual publication trends, authorship, countries, institutions, journals, and keywords to visualize emerging frontiers and influential factors. The authors assert that regulation of psychedelic drugs is necessary but should not impede scientific progress.