Ketamine attenuates kidney damage and depression-like behaviors in mice with cisplatin-induced acute kidney injury.
Translational psychiatry November 9, 2024 Tianwen Huang, Yangyang He, Ruijuan Cheng et al. 5 citations
In mice with cisplatin-induced acute kidney injury (AKI), a single dose of ketamine reduced kidney damage, pathological changes in other organs, and depression-like behaviors. The beneficial effects were reversed by blocking the TrkB receptor, and analysis implicated the TrkB and ERK-CREB signaling pathways and blood metabolites like C16-ceramide. The findings suggest ketamine may alleviate both kidney injury and associated depressive symptoms, though the role of the kidney-brain axis remains unclear.