Intravenous ketamine infusions in patients with depression and Epilepsy: Case series.
Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia December 1, 2024 Mariusz Stanisław Wiglusz, Zuzanna Chmielewska, Wiesław Jerzy Cubała 1 citation
Low-dose intravenous ketamine was safe and well tolerated in six patients with both depression and epilepsy. Side effects were mild and temporary, and no worsening of seizures occurred. Four of the six patients showed a significant reduction in depression scores on the Montgomery-Åsberg Depression Rating Scale, with two achieving full remission. Three patients reported a subjective decrease in seizure activity over twelve months. No serious adverse events happened. The authors caution that this is a small, post-hoc observation and that larger prospective studies are needed to confirm effects on seizures, depression, and side effects.