Effect of ketamine on task-based functional magnetic resonance imaging findings in major depressive disorder: A mini-review.
Journal of affective disorders February 1, 2025 Farzaneh Ramezani, Peyman Mardani, Fatemeh Nemati et al. 4 citations
Ketamine alters brain activity in people with major depressive disorder, particularly in the anterior cingulate cortex, dorsolateral prefrontal cortex, and amygdala. Most reviewed studies found that these changes in brain activity correlate with improvements in depressive symptoms, involving the prefrontal cortex, ACC, and cortico-cerebellar circuits. The review notes a lack of longitudinal data on lasting effects and a small number of studies. It calls for more research on ketamine's mechanisms, long-term impact, dose-response optimization, and comparisons with other fast-acting antidepressants.