Joint administration of sub-threshold doses of the acetylcholinesterase inhibitor donepezil with those of the NMDA receptor antagonist ketamine improved rats' recognition memory abilities.
Neuroscience letters November 20, 2024 Angeliki Metaxia Styla, Nikolaos Pitsikas 2 citations
A combination of low, individually inactive doses of donepezil (0.3 mg/kg) and ketamine (1 mg/kg) given after training prevented impairments in both non-spatial and spatial recognition memory in rats. The findings, though preliminary, suggest that pairing these two drugs might offer a new approach for treating memory problems common in Alzheimer's disease.