Exploring the Therapeutic Potential of N-Methyl-D-Aspartate Receptor Antagonists in Neuropathic Pain Management.
International journal of molecular sciences October 16, 2024 Ciprian Pușcașu, Cornel Chiriță, Simona Negreș et al. 14 citations
Neuropathic pain, a complex condition affecting millions worldwide, often responds poorly to existing treatments with significant side effects. This review examines N-methyl-D-aspartate receptor (NMDAR) antagonists—ketamine, memantine, methadone, amantadine, carbamazepine, valproic acid, phenytoin, dextromethorphan, riluzole, and levorphanol—as potential therapies. By analyzing preclinical and clinical studies, the authors evaluate these agents' efficacy for neuropathic pain relief, highlighting the growing interest in targeting NMDARs.