Effect of different doses of esketamine on the median effective concentration of propofol for inhibiting body movement during hysteroscopy.
Scientific reports October 24, 2024 Ji-Xiang Wan, Si-Si Zeng, Zhi-Qiang Wu et al. 4 citations
Adding esketamine to propofol anesthesia for hysteroscopy reduces the amount of propofol needed to prevent body movement during surgery. In a study of 90 patients, three different doses of esketamine (0.1, 0.2, and 0.3 mg/kg) were tested. The median effective concentration (EC50) of propofol decreased as the esketamine dose increased: from 3.849 μg/ml with the lowest dose to 3.417 μg/ml with the highest dose. The 0.3 mg/kg dose of esketamine was identified as optimal, also lowering patients' anxiety and depression scores 24 hours after surgery.