Nathaniel L Phillips

Department of Psychology, University of Georgia, Athens, GA, USA.

2 papers in the library · 14 citations · publishing 2024-2025

Papers

Treatment Approaches for Posttraumatic Stress Disorder Derived From Basic Research on Fear Extinction.

Biological psychiatry February 15, 2025 Jessica L Maples-Keller, Laura Watkins, Natalie Hellman et al. 12 citations

Treatment approaches for posttraumatic stress disorder (PTSD) based on fear conditioning and extinction models are reviewed. Fear extinction provides a translational model linking basic research in nonhuman animals to human treatments such as prolonged exposure therapy. Cognitive aspects of extinction, including consolidation and reconsolidation, are discussed along with behavioral and pharmacological strategies for preventing and treating chronic PTSD. Augmentation strategies reviewed include disrupting noradrenergic processes, NMDA receptor medications, physical exercise, cannabinoids, estradiol, dexamethasone, yohimbine, losartan, dopamine, and MDMA, with evidence for their efficacy in human samples. Limitations and future directions are also addressed.

DOI: 10.1016/j.biopsych.2024.07.010 Full text Combination treatment Exposure therapy Fear extinction Translational +5

Rapid Effects of MDMA Administration on Self-Reported Personality Traits and Affect State: A Randomized, Placebo-Controlled Trial in Healthy Adults.

Journal of psychoactive drugs October 23, 2024 Jessica L Maples-Keller, Courtland S Hyatt, Nathaniel L Phillips et al. 2 citations

A randomized, placebo-controlled trial with 34 healthy adults examined whether a single dose of MDMA alters five-factor model personality traits and affective states 48 hours later. No statistically significant changes were observed for the four pre-registered hypotheses, but medium effect sizes emerged: trait Openness increased (d = .79) and Positive Affect increased (d = .51) compared to placebo. These preliminary findings suggest MDMA may produce short-term shifts in openness and positive mood, warranting larger, longer-term studies to clarify how such changes might inform MDMA-assisted therapy.

DOI: 10.1080/02791072.2024.2420044 Full text Affect Clinical trial Psychedelic research Clinical psychology +3