Ketamine and α-Amino-3-Hydroxy-5-Methyl-4-Isoxazolepropionic Acid (AMPA) Receptor Potentiation in the Somatosensory Cortex: A Comprehensive Review.
Cureus September 1, 2024 Kaustuv Das, Jayshree Sen, Aishwarya S Borode
Ketamine, known for blocking NMDA receptors, also enhances AMPA receptor function, which may improve sensory processing in the somatosensory cortex. This review of preclinical and clinical studies suggests that ketamine's modulation of AMPA receptors, which are crucial for fast excitatory neurotransmission and synaptic plasticity, contributes to its therapeutic effects, including rapid antidepressant action. The findings indicate potential for ketamine-based therapies to treat sensory processing disorders and refine treatment strategies for mood disorders. A deeper understanding of these mechanisms could guide targeted interventions.