Ketamine modulates the exploratory dynamics and homebase-related behaviors of adult zebrafish.
Pharmacology, biochemistry, and behavior December 1, 2024 Camilla W Pretzel, João V Borba, Cássio M Resmim et al. 5 citations
Acute exposure to subanesthetic doses of ketamine (20 and 40 mg/L) increased total distance traveled in adult zebrafish, indicating hyperlocomotion. All tested concentrations (2, 20, and 40 mg/L) elicited circling behavior, a stereotyped-like response that diminished over time. Ketamine also reduced thigmotaxis and homebase activity while increasing the average length of trips, suggesting anxiolytic-like effects on spatio-temporal exploratory dynamics. These findings support ketamine's modulatory influence on behavior and highlight homebase-related measurements as useful for assessing behavioral changes in zebrafish models.