Behavioural brain research
January 1, 2013
Jonathan Cachat, Evan J Kyzar, Christopher Collins et al.
112 citations
Ibogaine, a psychoactive compound from the iboga plant, alters multiple behaviors in adult zebrafish. At doses of 10 and 20 mg/L, it reversed the natural diving response, causing initial top swimming followed by bottom dwelling, and reduced the innate preference for dark environments. It did not change overall locomotion or wall-hugging behavior but altered spatial exploration, promoted mirror interaction, disrupted group cohesion, and induced color changes from melanophore aggregation. Brain c-fos expression and whole-body cortisol levels remained unchanged. These results demonstrate ibogaine's complex pharmacological profile and support the use of zebrafish for studying hallucinogenic drug effects.
Behavioural brain research
July 14, 2017
Allan V Kalueff, Aleksandra Kaluyeva, Emeline L Maillet
21 citations
Noribogaine, the main psychoactive metabolite of ibogaine, produces robust anxiolytic-like behavior in adult zebrafish without affecting locomotion. In a 5-minute novel tank test following acute 20-minute immersion in 1, 5, or 10 mg/L noribogaine, treated fish spent more time and made more transitions to the top half compartment and showed fewer freezing bouts compared to controls. These results indicate noribogaine modulates components of the acute stress response related to emotionality and anxiety, suggesting it may be a potentially useful non-sedative anxiolytic agent.
Pharmacology, biochemistry, and behavior
December 1, 2024
Camilla W Pretzel, João V Borba, Cássio M Resmim et al.
5 citations
Acute exposure to subanesthetic doses of ketamine (20 and 40 mg/L) increased total distance traveled in adult zebrafish, indicating hyperlocomotion. All tested concentrations (2, 20, and 40 mg/L) elicited circling behavior, a stereotyped-like response that diminished over time. Ketamine also reduced thigmotaxis and homebase activity while increasing the average length of trips, suggesting anxiolytic-like effects on spatio-temporal exploratory dynamics. These findings support ketamine's modulatory influence on behavior and highlight homebase-related measurements as useful for assessing behavioral changes in zebrafish models.
Neurotoxicology and teratology
January 1, 2017
Tatiana O Kolesnikova, Sergey L Khatsko, Vadim A Shevyrin et al.
Tiletamine, a veterinary anesthetic related to ketamine, produces dose-dependent sedative effects in adult zebrafish. Immersion in 1 mg/L caused only reduced top entries in a novel tank test, while 5 and 10 mg/L caused robust sedation and skin darkening. Brain samples confirmed tiletamine presence only at the two higher doses. The results demonstrate potent neurotropic effects of tiletamine in zebrafish and support the use of fish-based aquatic screens for studying NMDA receptor antagonists.