Efficacy of single and repeated ketamine administration for suicidal ideation in adults with psychiatric disorders: A meta-analysis.
Progress in neuro-psychopharmacology & biological psychiatry January 10, 2025 Wanting Feng, Chengfeng Chen, Yexian Zeng et al. 9 citations
A meta-analysis of 49 clinical trials with 3,982 participants found that a single dose of ketamine significantly reduces suicidal ideation within 4 hours, with the strongest effect at 24 hours, and benefits lasting up to one month. Repeated doses also produced similar anti-suicidal effects at treatment endpoint and beyond one month. There was no statistical difference in efficacy or duration between single and multiple doses. The analysis suggests that even a single ketamine administration may provide a rapid and lasting reduction in suicidal thoughts.