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Chan Li

School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, People's Republic of China.

2 papers in the library · 4 citations · publishing 2024-2026

Papers

Impact of Altered Gut Microbiota on Ketamine-Induced Conditioned Place Preference in Mice.

Neuropsychiatric disease and treatment January 1, 2024 Chan Li, Chen Zhu, Genghong Tu et al. 4 citations

Repeated ketamine administration (20 mg/kg) induces conditioned place preference (CPP) in mice, a model of addiction, and significantly alters gut microbiota diversity and composition. Compared to controls, ketamine exposure increased the relative abundance of four microbial families (Lachnospiraceae, Ruminococcaceae, Desulfovibrionaceae, Family-XIII) and decreased one (Prevotellaceae). At the genus level, five genera increased and one decreased. Ketamine dependence reduced levels of tight junction proteins, GABA, and GABRA1, while increasing BDNF and 5-HT. However, an oral antibiotic cocktail that created pseudo-germ-free mice did not enhance ketamine-induced addictive behavior, suggesting the gut microbiota mediates ketamine-induced CPP.

DOI: 10.2147/NDT.S476420 Full text Substance use disorder Bdnf Gabra1 Gut-brain axis +7

Microbiota-Derived SCFAs Mediate the Synergistic Antidepressant Effects of Dajianzhong Decoction and Ketamine via FFAR2-NLRP3-IL-1β Signaling.

Pharmaceuticals (Basel, Switzerland) May 31, 2026 Wenting Zhang, Xin Guo, Jiping Zhang et al.

Combining the herbal formula Dajianzhong Decoction (DJZT) with ketamine produces synergistic antidepressant effects in a mouse model of depression. The combination restores levels of short-chain fatty acids (SCFAs), particularly acetic acid and isobutyric acid, in the gut. These SCFAs activate the FFAR2 receptor in the brain's medial prefrontal cortex, which suppresses NLRP3-IL-1β-driven neuroinflammation and reverses synaptic deficits. Blocking FFAR2 with the inhibitor GLPG0974 eliminates these benefits. The findings suggest that the SCFA-FFAR2-NLRP3-IL-1β axis mediates the prolonged antidepressant action of the combined treatment, pointing to microbiota-modulating strategies for improving ketamine therapy.

DOI: 10.3390/ph19060877 Full text Depression Ketamine Djzt Ffar2–nlrp3–il-1β +2