Esketamine improves cognitive function in sepsis-associated encephalopathy by inhibiting microglia-mediated neuroinflammation.
European journal of pharmacology November 15, 2024 Hui Li, Wen Hu, Zhen Wu et al. 11 citations
Esketamine improves cognitive impairments and alleviates neuronal damage in mice with sepsis-associated encephalopathy by inhibiting microglia-mediated neuroinflammation. The beneficial effects of Esketamine on microglia and cognitive behavior were counteracted by the BDNF receptor antagonist K252a in both in vivo and in vitro experiments. These results suggest that Esketamine inhibits microglia-mediated neuroinflammation by activating the BDNF pathway, thereby mitigating neuronal damage and cognitive dysfunction associated with sepsis-associated encephalopathy.