Esketamine improves cognitive impairments and alleviates neuronal damage in mice with sepsis-associated encephalopathy by inhibiting microglia-mediated neuroinflammation. The beneficial effects of Esketamine on microglia and cognitive behavior were counteracted by the BDNF receptor antagonist K252a in both in vivo and in vitro experiments. These results suggest that Esketamine inhibits microglia-mediated neuroinflammation by activating the BDNF pathway, thereby mitigating neuronal damage and cognitive dysfunction associated with sepsis-associated encephalopathy.
A 21-day program combining daily nasal breathing regulation, spontaneous mandala drawing, and descriptive journaling, with weekly group sharing, heightened interoceptive awareness and mind-body integration among 11 urban adults in mainland China. Three interrelated processes emerged: refinement of bodily attention, a shift from deliberate control to natural immersion, and symbolization of feeling through artistic expression and social resonance. A non-goal-directed, relaxed practice style helped transition from control to absorption, activating self-regulatory mechanisms. Non-evaluative awareness deepened flow and supported cognitive reorganization. The study outlines a pathway by which breath-triggered interoceptive work operates within mind-body interventions.