Effects of acute and chronic ketamine administration on spontaneous and evoked brain activity.
Brain research January 1, 2025 Ernestas Cizus, Urte Jasinskyte, Robertas Guzulaitis 3 citations
Acute suppression of NMDA receptors in mice alters brain oscillations across a wide frequency spectrum and diminishes oscillatory potency in evoked responses, paralleling changes seen in schizophrenia. Chronic suppression of NMDA receptors did not produce the expected cumulative effect on brain activity. The findings highlight robust yet similar impacts of acute and chronic NMDA receptor suppression on brain oscillations, contributing to a nuanced understanding of rodent models of schizophrenia.