Evaluation of the Effects of Repetitive Anaesthesia Administration on the Brain Tissues and Cognitive Functions of Rats with Experimental Alzheimer's Disease.
Medicina (Kaunas, Lithuania) August 5, 2024 Nuray Camgoz Eryilmaz, Mustafa Arslan, Aysegul Kucuk et al. 3 citations
In elderly rats with streptozotocin-induced Alzheimer's disease, repeated administration of ketamine, propofol, or their combination improved cognitive performance on the radial arm maze test compared to untreated Alzheimer's rats. Ketamine and the ketamine-plus-propofol group showed improvement after the first anesthesia, while propofol alone improved after the second. The treatments also reduced oxidative stress markers (lower TBARS, higher catalase and paraoxonase-1 activity) and lessened histopathological changes in brain tissue. Apoptosis-related protein expression shifted favorably, with decreased caspase-3 in the combination group. The results suggest that repeated anesthesia can positively affect cognitive functions in this Alzheimer's model.