Exploring the interplay of chronic toxoplasmosis and NMDAR dysfunction: Insights into schizophrenia-like behaviors and therapeutic potential.
Open veterinary journal July 1, 2024 Seyedeh Mina Masoumi, Mohammad Reza Youssefi, Seyed Shapoor Reza Shojaei 2 citations
Chronic infection with Toxoplasma gondii and ketamine treatment both produce schizophrenia-like symptoms in mice, including hyperactivity, anxiety, and memory problems. Both conditions also lowered antioxidant enzyme levels and increased lipid peroxidation in the brain, along with reduced expression of NMDA receptor subunits NR1 and NR2A. Treatment with sulfadiazine-trimethoprim partially reversed the NMDA receptor downregulation but did not correct all behavioral changes. The findings highlight a link between chronic toxoplasmosis, NMDA receptor dysfunction, and schizophrenia-like behaviors, suggesting potential targets for treating cognitive and neurological impairments.