Sex-specific effects of subchronic NMDA receptor antagonist MK-801 treatment on hippocampal gamma oscillations.
Frontiers in neuroscience January 1, 2024 Tim Simon Neuhäusel, Zoltan Gerevich 5 citations
Blocking NMDA receptors with the drug MK-801 for 14 days in rats impaired recognition memory, increased stereotypic behavior, and reduced grooming, predominantly in females. The drug also boosted the peak power of hippocampal gamma oscillations induced by kainate or acetylcholine only in female rats, without changing oscillation frequency. These results align with clinical electrophysiological findings and underscore hippocampal gamma oscillations as a biomarker in schizophrenia and depression, highlighting sex-specific effects of NMDA receptor antagonists.