Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, USA; Department of Anaesthesia, Harvard Medical School, Boston, USA; Department of Immunology, Harvard Medical School, Boston, USA. Electronic address: koichi.yuki@childrens.harvard.edu.
1 paper in the library · 4 citations · publishing 2024
Ketamine, an anesthetic, reduces levels of the DISC1 protein in the brains of newborn rats, which is linked to increased activity of GSK-3β, an enzyme involved in cell signaling. This reduction corresponds to decreased axonal growth and increased cell death. Lithium, a GSK-3β antagonist, reverses these effects, suggesting a connection between DISC1 and ketamine-induced neurodegeneration.