Sex difference alters the behavioral and cognitive performance in a rat model of schizophrenia induced by sub-chronic ketamine.
Journal of psychiatric research October 1, 2024 Mohammad-Ali Samizadeh, Seyedeh-Tabassom Abdollahi-Keyvani, Hamed Fallah et al. 21 citations
In a rat model of schizophrenia induced by five daily injections of ketamine (30 mg/kg), recognition memory was impaired and brain-derived neurotrophic factor (BDNF) levels in the prefrontal cortex decreased in both sexes. Ketamine also lowered pain threshold in females, increased rearing behavior in males, and caused greater hyperlocomotion in females. Subsequent treatment with risperidone (2 mg/kg) restored or attenuated all these behavioral effects and BDNF levels. The findings suggest sex differences in how ketamine affects pain perception, locomotion, and rearing behavior in this model.