Case report: two cases of rhabdomyolysis following esketamine treatment.
Frontiers in psychiatry January 1, 2024 René Zeiss, Melissa Schweizer, Bernhard Connemann et al. 3 citations
Two cases of rhabdomyolysis, a destruction of muscle tissue with elevated creatine kinase levels, occurred after administration of nasal esketamine for treatment-resistant depression. A 33-year-old male patient developed muscle pain and fatigue after the fourth dose, with creatine kinase levels above 22,000 U/L. A 22-year-old male patient exhibited muscle weakness and elevated creatine kinase levels (8,032 U/L) after the tenth dose. In both cases, creatine kinase levels returned to normal after discontinuation of esketamine and supportive care. The temporal connection suggests a possible causal relationship. No prior literature on esketamine-induced rhabdomyolysis following nasal administration was found.