Out-of-Hospital Intranasal Ketamine as an Adjunct to Fentanyl for the Treatment of Acute Traumatic Pain: A Randomized Clinical Trial.
Annals of emergency medicine October 1, 2024 Jason T McMullan, Christopher A Droege, Kathleen M Chard et al. 5 citations
Adding 50 mg of intranasal ketamine to fentanyl for out-of-hospital treatment of acute traumatic pain did not improve pain control compared to fentanyl alone. In a randomized, placebo-controlled trial of 192 male trauma patients aged 18 to 65, there was no difference in the proportion who experienced at least a 2-point reduction in pain 30 minutes after treatment (44.7% with ketamine versus 36.0% with placebo) or at any time through 3 hours. Side effects and need for additional pain medications were also similar between groups. The results suggest no analgesic benefit from this dose of intranasal ketamine in this setting.