Comparing the adverse effects of ketamine and esketamine between genders using FAERS data.
Frontiers in pharmacology January 1, 2024 Xinxia Yang, Dongdong Chen 10 citations
Adverse drug events from ketamine and esketamine differ between men and women. Analyzing reports from the FAERS database between 2004 and 2023, 2907 female and 1634 male esketamine reports showed that completed suicide, decreased therapeutic product effects, urinary retention, and hypertension were more common in men. For ketamine, 552 female and 653 male reports indicated that toxicity to various agents, bradycardia, cystitis, and agitation were more likely in men, while women were more likely to develop suicidal ideation, increased transaminase levels, sclerosing cholangitis, and sterile pyuria. These gender differences should guide individualized clinical treatment.