A randomised, open-label, pragmatic pilot comparison of oral and intravenous ketamine in treatment-resistant depression.
Asian journal of psychiatry September 1, 2024 Pn Suresh Kumar, Vikas Menon, Chittaranjan Andrade 12 citations
In outpatients with treatment-resistant depression, oral ketamine was better tolerated than intravenous (IV) ketamine, with a lower dropout rate (26.7% vs 54.8%). Depression ratings and response and remission rates did not differ between the two groups at day 14 or day 30. Adverse events such as headache (56.7% vs 74.2%) and drowsiness (0.0% vs 22.6%) were less common with oral ketamine. However, conclusions about relative antidepressant efficacy cannot be drawn due to the high dropout rate in the IV group.