mTORC1 activation in presumed classical monocytes: observed correlation with human size variation and neuropsychiatric disease.
Aging July 26, 2024 Karl Berner, Naci Oz, Alaattin Kaya et al. 1 citation
Gain of function disturbances in nutrient sensing are likely the largest component in human age-related disease. Mammalian target of rapamycin complex 1 (mTORC1) activity affects health span and longevity. The drugs ketamine and rapamycin are effective against chronic pain and depression, and both affect mTORC1 activity. In a study of 27 females with psychiatric disease, phosphorylated p70S6K, a marker for mTORC1 activity, was measured in blood samples. mTORC1 activity correlated with biometrics (height, macrocephaly, pupil distance) and neuropsychiatric profiles (anxiety, autism). Phosphorylated p70S6K was the best predictor for ketamine response across all cases and for rapamycin response in one instance. The data suggest a simple assay may allow cost-effective prediction of medication response.