High-order brain interactions in ketamine during rest and task: a double-blinded cross-over design using portable EEG on male participants.
Translational psychiatry July 27, 2024 Rubén Herzog, Florentine Marie Barbey, Md Nurul Islam et al. 13 citations
Ketamine increases redundancy in brain dynamics—copies of the same information retrievable from three or more electrodes—most notably in the alpha frequency band, as measured by portable low-density EEG. In a double-blind crossover trial with 30 male adults, racemic ketamine compared to saline infusion produced greater redundancy during resting state, linked to dissociative shifts in consciousness. During an auditory oddball task, the effect was stronger for predictable standard stimuli than for deviant ones. Associations between ketamine's high-order interactions and experiences of derealization were observed, suggesting these measures capture pharmacological alterations in consciousness.