Key Laboratory of Integrative Biomedicine for Brain Diseases, School of Chinese Medicine, Nanjing University of Chinese Medicine, Nanjing, 210023, China.
2 papers in the library · 24 citations · publishing 2024-2025
The neuropeptide PACAP in the hippocampal dentate gyrus (DG) mediates rapid antidepressant responses. Chronic paroxetine increased hippocampal PACAP, and blocking PACAP in the DG slowed the antidepressant effect. PACAP levels were reduced in two depression models, and knocking down PACAP in the DG caused depression-like behaviors. A single infusion of PACAP into the DG produced a rapid and sustained antidepressant effect in normal and stressed mice. Optogenetic excitation of PACAP-expressing neurons instantly elicited antidepressant responses, while inhibition induced depression-like behaviors. PACAP infusion inhibited CaMKII-eEF2 signaling and activated mTOR-BDNF signaling. Acute ketamine increased PACAP, and blocking PACAP attenuated ketamine's rapid antidepressant effect.
An eight-week, online-delivered mindfulness program is being tested for feasibility and acceptability in people over 60 with mild cognitive impairment or mild dementia in the UK. The study will recruit 32 participants who will attend weekly live online sessions led by an experienced teacher, plus daily home practice. Primary outcomes are feasibility and acceptability measured through participation records and interviews. Secondary outcomes include changes in cognition, mood, sleep, quality of life, mindfulness, and resilience. Online delivery could reduce travel burdens and costs, and the study aims to provide evidence supporting remote interventions for this population.