Cognitive changes in patients with unipolar TRD treated with IV ketamine: A systematic review.
Progress in neuro-psychopharmacology & biological psychiatry December 20, 2024 Veronica Grasso, Gilmar Gutierrez, Najat Alzbeidi et al. 9 citations
Unipolar treatment-resistant depression is linked to cognitive impairment. A systematic review of fourteen studies found that intravenous ketamine treatment shows promise for improving neurocognitive function in these patients, including processing speed, working memory, verbal and visual memory, executive function, attention, emotional processing, and auditory verbal episodic memory. One study reported negative effects on verbal memory. The evidence had a low risk of bias, but limitations include small sample sizes, heterogeneity, and a predominantly female, Western, and Caucasian population, constraining generalizability. Further research is needed on long-term effects and confounders.