Department of Anesthesiology, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University/ Hunan Cancer Hospital, Changsha, Hunan, China; Department of Medicine, Hengyang Medical School, University of South China, Hengyang, China.
2 papers in the library · 7 citations · publishing 2024-2025
In a rat model of neuropathic pain caused by nerve injury, low-dose esketamine relieved depression-like behaviors such as reduced mobility in a forced swim test and decreased preference for sucrose. The drug did not significantly change pain sensitivity. Proteomic analysis of the medial prefrontal cortex revealed that esketamine reversed the upregulation of mGluR5 and Homer1a proteins seen in the pain-depression model. The Homer1a–mGluR5 signaling pathway may underlie esketamine's antidepressant effect in neuropathic pain-related depression.
During the early COVID-19 pandemic, expectant fathers in China reported moderate levels of applied mindfulness, with the highest scores for positive emotion regulation and the lowest for decentering. Urban residence, higher education, and higher income were associated with greater mindfulness. Fathers' mindfulness scores were positively correlated with those of their pregnant partners, suggesting a dyadic pattern. The findings highlight the role of both individual and couple-level factors in coping with pandemic stress among expectant fathers.