Over the past 20 years, research on NMDA receptors as targets for depression treatment has grown steadily, with 5,092 publications identified. The United States leads in collaborations, publications, and citations. Co-cited reference analysis revealed 15 main clusters. Recent hotspots include ketamine (an NMDA receptor antagonist) for treatment-resistant depression, oxidative stress, synaptic plasticity, and neuroplasticity-related factors such as brain-derived neurotrophic factor. While ketamine's application and mechanisms in major depressive disorder remain a hot topic, its side effects have spurred investigation into new rapid-acting antidepressants.
A systematic review of 19 papers from IEEE and ACM databases examined how virtual reality technology is used in meditation research. The review found no existing guidelines or comprehensive reviews on conducting such studies. It analyzed meditation types, design considerations, and VR technologies employed in the eligible studies, and identified research opportunities and challenges for future work in this area.