Immediate and long-term electrophysiological biomarkers of antidepressant-like behavioral effects after subanesthetic ketamine and medial prefrontal cortex deep brain stimulation treatment.
Frontiers in neuroscience January 1, 2024 Matthew Bergosh, Sasha Medvidovic, Nancy Zepeda et al. 6 citations
In a rat model of depression, both ketamine and deep brain stimulation (DBS) of the medial prefrontal cortex altered specific brain wave patterns. Depression-like behavior correlated with reduced theta power and increased signal complexity (sample entropy) during treatment, and later with a higher theta peak frequency and a lower aperiodic exponent. Ketamine's remission-like effects were linked to post-treatment increases in aperiodic offset and exponent, and decreased sample entropy. DBS alone produced immediate decreases in sample entropy, sustained increases in low gamma peak width and aperiodic offset, and lasting cognitive improvements.