Effects of N-Methyl-d-Aspartate Receptor Antagonists on Gamma-Band Activity During Auditory Stimulation Compared With Electro/Magneto-encephalographic Data in Schizophrenia and Early-Stage Psychosis: A Systematic Review and Perspective.
Schizophrenia bulletin August 27, 2024 Bianca Bianciardi, Helena Mastek, Michelle Franka et al. 6 citations
A systematic review of 15 preclinical and 3 human studies found that NMDA receptor antagonists reduce evoked gamma-band power and intertrial phase coherence in auditory processing, while sometimes increasing baseline gamma-band activity. These changes partially match the reductions in gamma-band spectral power and intertrial phase coherence observed in 37 studies of schizophrenia patients and 9 studies of early-stage psychosis. However, baseline gamma-band findings were inconsistent across studies, and a publication bias was noted in the schizophrenia patient literature. The results support the idea that NMDA receptor hypofunction contributes to altered excitation/inhibition balance and auditory gamma-band deficits in schizophrenia.