Efficacy and Safety of Pharmacological Treatment in Patients with Complex Regional Pain Syndrome: A Systematic Review and Meta-Analysis.
Pharmaceuticals (Basel, Switzerland) June 20, 2024 He Zhu, Bei Wen, Jijun Xu et al. 15 citations
A systematic review and meta-analysis of 23 randomized controlled trials involving 1029 patients with complex regional pain syndrome found that bisphosphonates and ketamine each provide long-term (beyond one month) pain relief, though neither showed statistically significant short-term benefit. Both treatments caused mild adverse events that required no special intervention. Ketamine and bisphosphonates appeared to be the best pharmacological strategies for pain relief in CRPS.