Ketamine's Amelioration of Fear Extinction in Adolescent Male Mice Is Associated with the Activation of the Hippocampal Akt-mTOR-GluA1 Pathway.
Pharmaceuticals (Basel, Switzerland) May 22, 2024 Emilija Glavonic, Milorad Dragic, Milos Mitic et al. 5 citations
A single dose of ketamine (10 mg/kg) improved fear extinction in adolescent male mice, likely by enhancing the consolidation or recall of extinction memory. Ketamine increased activity of Akt and mTOR signaling and raised levels of GluA1 and GluN2A proteins in the hippocampus, and upregulated BDNF exon IV mRNA in both the hippocampus and prefrontal cortex. It also increased c-Fos expression in the ventral hippocampus and left infralimbic ventromedial prefrontal cortex. These findings suggest that ketamine's effects on adolescent fear extinction involve activation of hippocampal Akt-mTOR-GluA1 signaling, with the ventral hippocampus and left infralimbic prefrontal cortex as neural correlates.